Tuesday, 6th June 50 Years Shine-Dalgarno Symposium 2023

Synopsis

While mRNA therapeutics have been in development for decades, the COVID-19 pandemic saw this technology come of age with mRNA vaccines becoming available at unprecedented speed. Please join Moderna for this interactive session that will explore the potential of the mRNA platform to address a range of unmet public health challenges from infectious diseases to cancer.

The session will begin with a Moderna presentation on public health challenges, Moderna’s mRNA platform and Moderna’s commitment to R&D and manufacturing in Australia. A panel discussion will follow, featuring four leading Australian researchers who are collaborating with Moderna to develop novel mRNA-based therapeutics. The session is designed to be interactive and will include plenty of time for audience questions.

Panelists

• Professor Heidi Drummer (Burnet Institute, VIC)
• Associate Professor Nick West (University of Queensland, QLD)
• Dr Kerrie Sandgren (University of Sydney, NSW)
• Dr Vincent Corbin (University of Melbourne / Doherty Institute, VIC)

Schedule

3:05-3:15pm: Dr Simon Hardwick (Moderna)

3:15-3:40pm: Panel discussion

3:40pm-close: Audience Q&A with panel

• The mammalian oocyte as a cell system to study control of cytoplasmic polyadenylation - Lemia Bickalo
• Residual Bodies: Wasteland or Treasure Island? - Mohd Nazmul Hasan Apu
• Mechanisms producing novel polyadenylated isoforms of ncRNA RPPH1 - Kiarna Kavanagh-Beck
• A new class of TLR7 inhibitors to treat autoimmunity - Arwaf Alharbi
• Transcription Termination Using Atypical Factors in Diverse Bacterial Genomes - Sofia Magalhaes Moreira
• Incorporating RNA Secondary-Structure to Improve Viral Phylogenetics and Drug-Target Design - Rosa E Prahl
• Voluntary Exercise Modulates Pathways Associated with Age-related Macular Degeneration Including Inflammation and Maintenance of Extracellular Matrix - Nicholas W Bariesheff
• Stress Granules and P-bodies exhibit unique morphologies and transcriptomes during stress - Savannah O'Connell
• Trimeric oligonucleotides ameliorate disease in a mouse model of CLE-like inflammatory skin disease. - Sunil Sapkota
• Characterising the non-coding RNA profile of retinal immune cells in response to neurodegeneration - riemke Aggio-Bruce
• The interplay between microRNAs and long non-coding RNAs in HPV16 related Oropharyngeal cancers - Dayna Sais
• Molecular Assembly and Formation of Paraspeckles - Adiba Ms Anjum
• How Exercise Protects Against Choroidal Neovascularisation: a Transcriptomic Study - Marissa Ellis
• Investigating the impact of a disease-causative mutation in the RNA editing enzyme ADAR1 on mouse development - ZHEN LIANG
• What is the Role of the Ancient miR159-GAMYB Pathway? - Ejiroghene Evivie
• Characterisation of lncRNA interactions and their impact on genome architecturein Arabidopsis thaliana - Selene L Fernandez-Valverde
• The Transcriptional and Post-transcriptional Regulations in Retinal Degeneration - Lixinyu Liu
• Hacking cell death: Impairing Gasdermin D mediated pyroptosis is protective against retinal degeneration - Rakshanya Sekar
• CCAAT enhancer binding proteins mediate retinal degeneration - Adrian Cioanca
• Using microRNA isoforms to predict disease status - Alex L McAllan
• ESRP1 controls biogenesis and function of a large abundant multiexon circRNA - Greg Goodall
• First report of RNA editing in human retina – a process central to photoreceptor health, and a risk factor for both AMD and rarer macular degeneration - Brendan R E Ansell
• The non-coding RNA landscape in macrophages is altered by liver flukes in a quest for immune dominance. - Dayna Sais
• Discovery of parasite-derived isomiRs in mammalian host macrophages during infection - Sumaiya Chowdhury
• RNA Binding Motif Protein 47 (RBM47) C>U editing sites in the gut epithelium - David T Humphreys
• LncRNA LIMp27 regulates the DNA damage response through p27 in p53-defective cancer cells - Lei Jin
• GENOME-WIDE IDENTIFICATION OF LONG INTERSPERSED NUCLEAR ELEMENTS MODULATORS OF IMMUNITY - Renan ND Almeida
• Heterogeneous Nuclear Ribonucleoprotein U (HNRNP U) interaction with Ago1 is essential for siRNA-induced transcriptional/epigenetic silencing in human cells - Andleeb Hanif
• Delivery of siRNA inducing transcriptional/epigenetic silencing via Layer-by-Layer particles to the HIV-1 latent reservoir - Chantelle L Ahlenstiel
• The dynamic cancer cell translatome mediating cell plasticity and metastasis - Heloisa Helena Milioli
• Deciphering the role of introns in controlling translation - Gabrielle Chieng
• ZMYND8 knock-out leads to widespread transcriptional changes and impaired brain organoid development - Juli Wang
• Functional characterisation of active enhancers in human astrocytes using a CRISPRi screen - Nicole Green
• How do pentatricopeptide repeat proteins (PPR) bind to specific RNA sequences? - Nicholas Marzano
• Synaptic lncRNA in fear extinction learning and memory - Wei-Siang Liau
• Development of a scalable pipeline for RNA editing detection and annotation in RNAseq data - Jacob E Munro
• The Dark Matter of Cancer Relapse: Long Non-Coding RNAs and Drug Tolerance in Lung Cancer - William JH Davis
• PRIMITI: A machine learning model for identifying novel miRNA-target mRNA interactions - Korawich Uthayopas
• Enhanced identification of RNA modification sites using deep learning framework - Korawich Uthayopas
• Profiling messenger RNA modifications associated with translation in B-cell acute lymphoblastic leukemia. - Favour Oluwapelumi Oyelami
• Exploring post-transcriptional modifications during myrtle rust pathogen-plant interactions - Ashley Jones
• Nonsense-mediated decay machinery in Plasmodium falciparum is inefficient and non-essential - Emma McHugh
• Evaluating RNA integrity and fragmentation for accurate transcriptome-wide comparisons - Katrina Woodward
• G-U base-paired hairpin RNA is both a potent small RNA sponge and an effective RNAi inducer in plants - Chengcheng Zhong
• Editing 5’ UTRs to control protein production in plants - Rebeccah Tyrrell
• hRNase 4: A New Enzymatic Tool for mRNA Characterization by Mass Spectrometry - Selva Kumari Ramasubramanian
• Ribosome profiling at high-containment to understand Henipaviral translation  - Marina Alexander
• Cell-type-specific, compartment-specific, and state-dependent tagging of RNA by photoinducible proximity labelling in neurons - Joshua Davies
• Small RNAs are TRAPP’ed by a toxin-immunity complex in pathogenic E. coli - Jai J Tree
• Uncovering the role of the functional small RNA interactome in vancomycin tolerance in Staphylococcus aureus - Winton Wu
• MicroRNA-142-3p targets YES1 and TWF1 in human hepatocellular carcinoma to inhibit proliferation, migration and invasion, and to restore lenvatinib sensitivity - Khadijeh Mahboobnia
• Discovery of a Non-Coding RNA in a Novel Family of Transposases - Rezwan Siddiquee
• MicroRNA to MicroRNA interactions: miR-21 regulation of miR17~92a cluster in Head & Neck Squamous Cell Carcinoma - Sarah M Stapleton